We’ve gone through tubes and tubs of anti-aging creams, often testing new products before they launch. Though the packaging may change, the crème de la crème almost always contain a key ingredient: retinol. And we’re not the only ones to notice — dermatologists consistently recommend the wrinkle fighter because it’s scientifically proven to work.

In the past, slathering on the vitamin-A derivative was associated with redness and flaking, but those side effects can be easily avoided with today’s gentler treatments. We like DERMAdoctor‘s new Poetry in Lotion ($75) because it’s specifically formulated to reduce irritation, combining retinol’s intensive skin-refining properties with soothing extracts of Saint Johnswort, mallow and Indian frankincense. Even better, a little bit goes a long way (we smooth on just a tiny drop every other night), so each 1-ounce bottle lasts several months.

Want to give Poetry in Lotion a try? Click here for your chance to win a bottle!

Tags: Alcohols, Anti-aging cream, antioxidants, Chemistry, health, irritation, Lotion, Retinoids, Retinol, Skin care, USD, Vitamins